Analysis of the nuclear egress complex of mouse cytomegalovirus [Elektronische Ressource] / vorgelegt von Mark Lötzerich

Analysis of the nuclear egress complex of mouse cytomegalovirus Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften der Fakultät für Biologie der Ludwig-Maximilians-Universität München vorgelegt von Mark Lötzerich München, 2007 Dissertation eingereicht am: 28.03.2007 Erstgutachterin: PD Dr. Bettina Kempkes Zweitgutachter: Prof. Dr. Heinrich Leonhardt Sondergutachter: Prof. Dr. Ulrich H. Koszinowski Tag der mündlichen Prüfung: 19.12.2007 Table of contents A. Summary ...................................................................................................... 1 B. Introduction.................................................................................................. 2 1. The cytomegaloviruses as family members of the herpesviruses .................. 2 1.1 Biology of CMV infection and host immune defense .................................... 3 1.2 Transmission and clinical relevance of human cytomegalovirus (HCMV) .... 4 1.3 Mouse cytomegalovirus (MCMV) as animal model for HCMV infection ....... 5 2. Structure of cytomegaloviruses...................................................................... 5 3. Replication of cytomegaloviruses................................................................... 7 4. The nuclear envelope......................................