Signaling in the induction of genomic damage by endogenous compounds [Elektronische Ressource] = Signalwege bei der Induktion von Genomschäden durch endogene Substanzen / submitted by Gholamreza Fazeli

Signaling in the induction of genomic damage by endogenous compounds Signalwege bei der Induktion von Genomschäden durch endogene Substanzen Doctoral thesis for a doctoral degree at the Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg, Section Biomedicine submitted by Gholamreza Fazeli from Behbahan Würzburg 2010 Submitted on: …………………………………………………………..…….. Members of the Promotionskomitee: Chairperson: ………………………………………………………………....... Primary Supervisor: ………..………………..…… Prof. Dr. Helga Stopper Supervisor (Second): ………………………………… PD. Dr. Robert Hock Supervisor (Third): ………………………… Prof. Dr. Med. Frank Schweda Date of Public Defence: …………………………………………….………… Date of Receipt of Certificates: ………………………………………………. 3 Index Index Index ...........................................................................................................................3 Abbreviations ..............................................................................................................5 1 Introduction ..........................................................................................................8 1.1 Oxidative stress and its effects on biomolecules ..........................................8 1.2 Oxidative stress in human conditions .........................................................10 1.2.1 Renin-angiotensin-aldosterone-system and DNA damage..................10 1.2.