Leber's hereditary optic neuropathy (LHON) [Elektronische Ressource] : involvement of mitochondrial permeability transition in the pathogenesis and protective actions of minocycline / von Mohammad Fahad Haroon

Leber’s hereditary optic neuropathy (LHON): involvement of mitochondrial permeability transition in the pathogenesis and protective actions of minocycline Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) genehmigt durch die Fakultät für Naturwissenschaften der Otto-von-Guericke-Universität Magdeburg von M. Pharm. Mohammad Fahad Haroon geb. am 13. November 1976 in Aligarh, UP, Indien Gutachter: Prof. Gerald Wolf Prof. Wolfgang Kunz eingereicht am: 13.12.2007 verteidigt am: 24.06.2008 Acknowledgements ACKNOWLEDGEMENTS First and foremost my thanks and praises to the Almighty Allah who has blessed me with this opportunity and knowledge to proceed further, and a drive to excel in life. Without his guidance and blessings I have no tranquility of mind and no harmony of thought. I would like to thank wholeheartedly my supervisor and mentor Prof. Gerald Wolf for his willingness to guide me and giving me the chance to work under him. His scientifically directing discussions were the most productive of all. He showed me different ways to approach a research problem and the need to be persistent to accomplish any goal. His constant inspiration kept me motivated. Thanks to my co-supervisor Dr. Peter Kreutzmann who was actively involved in all the aspects of the project. He was a constant help in my write up and a regular source of motivation. Dr.