Integrating neurobiological markers of depression [Elektronische Ressource] : an fMRI-based pattern classification approach = Integration neurobiologischer Marker depressiver Erkrankungen mittels fMRT-basierter Musterklassifikation / submitted by Tim Hahn

Integrating neurobiological markers of depressionan: fMRI-based pattern classification approach Integration neurobiologischer Marker depressiver Ekrankungen mittels fMRT-basierter Musterklassifikation Doctoral thesis for a doctoral degree at the Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg, SectionN eurosciencesubmitted by Tim Hahn from Lennestadt Würzburg 2010 Submitted on: April 1, 2010 Members of the Promotionskomitee: Chairperson: Prof. Dr. Dr. Martin J. Müller Primary Supervisor: Prof. Dr. Andreas J. Fallgatter Supervisor (Second): Prof. Dr. Klaus-Peter Lesch Supervisor (Third): Prof. Dr. Martin A. Heisenberg Date of Public Defence: July 26, 2010 Date of Receipt of Certificates: “Prediction is very difficult, especially abouuret .t”h e futNiels Bohr (1885-1962) Table of Contents 0. Abstract..............................................................7.........1. Introduction......................................................1.1..........2. Part I – Integrating biomarkers: development of a lmtiu-source pattern classification algorithm .............................................1.4...............2.1. Approaches to classification....................................................................... 162.2. Goals and challenges of algorithm developmen.t.................................... 202.3. Algorithm development...................................2.2........................2.3.1. First-level prediction.