Environmental effects and gene-environment interactions [Elektronische Ressource] : air pollution and temperature effects on cardiovascular risk factors / Regina Hampel. Betreuer: Annette Peters

FromThe Institute of Medical Information Processing, Biometry andEpidemiology, Ludwig-Maximilians-University of Munich, GermanyChair of Epidemiology: Prof. Dr. Dr. H.-E. WichmannandThe Institute of Epidemiology II,Helmholtz Zentrum Munc¨ hen - German Research Center for EnvironmentalHealth (GmbH)Director: PD Dr. A. PetersEnvironmental Effects and Gene-Environment Interactions:Air Pollution and Temperature Effects on Cardiovascular RiskFactors.ThesisSubmitted for a Doctoral degree in Human Biology at the Faculty ofMedicine, Ludwig-Maximilians-University, Munich, GermanybyRegina HampelfromN¨ ordlingen2011With approval of the Medical Facultyof the Ludwig-Maximilians-University of MunichSupervisor/Examiner: PD Dr. Annette PetersCo-Examiners: PD Dr. Rudolf A. J¨ orresProf Dr. Jürgen StausbergCo-Supervisor: Dr. Alexandra SchneiderDean: Prof. Dr. med. Dr. h.c. M. Reiser,FACR, FRCRDate of oral examination: 15.12.2011CONTENTS 1Contents1 Summary 32 Zusammenfassung 53 Introduction 73.1 Cardiovascular health . . . . . . . . . . . . . . . . . . . . . . . 73.1.1 Blood biomarkers and electrogardiogram parameters . 73.1.2 Air pollution . . . . . . . . . . . . . . . . . . . . . . . 83.1.3 Air temperature . . . . . . . . . . . . . . . . . . . . . . 93.2 Specific aims and results . . . . . . . . . . . . . . . . . . . . . 103.3 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . .