Biogenesis and function of mitochondrial outer membrane proteins [Elektronische Ressource] / von Shukry James Habib

Biogenesis and Function of Mitochondrial Outer Membrane Proteins Dissertation zur Erlangung des Doktorgrades des Fachbereichs für Biologie der Ludwig-Maximilians Universität München von Shukry James Habib aus Jish/Israel München 2006 Mündliche Prüfung am: 13.12.2006 Sondergutachter: Herr Prof. Dr. Dr. Walter Neupert 1. Gutachter: Herr Prof. Dr. Reinhold Herrmann 2. Gutachter: Herr Prof. Dr. Hugo ScheerCONTENTS 1. Introduction 1 1.1 Mitochondrial structure and function 1 1.2 biogenesis 2 1.2.1 Overview on protein translocation into mitochondria 2 1.2.2 targeting signals 3 1.2.3 Interaction of cytosolic chaperones with precursor proteins 5 1.2.4 Cotranslational versus posttranslatioinal import 6 1.2.5 Translocation across the outer membrane 7 1.2.6 The TIM23 translocase 10 1.2.7 TIM22 12 1.2.8 OXA1 translocase 13 1.3 Biogenesis of mitochondrial outer membrane proteins 14 1.3.1 Topologies of mitochondrial outer membrane proteins 14 1.3.2 Targeting sequences of mitochondrial outer membrane proteins 15 1.3.2.1 The targeting sequence of signal anchored proteins 15 1.3.2.2 The sorting sequence of tail anchored proteins 15 1.3.3 Biogenesis of β-barrel membrane proteins 17 1.3.3.